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Rail manufacturer Alstom is to close its Preston site, which employs 180 members of staff.
The French company said it would shift its North West attentions to the Widnes depot, which it described as "the natural home for [our] increasingly digitally focussed business".
A company statement said: "Alstom has recently opened its new Transport Technology Centre in Widnes in the Liverpool City Region. We plan to centralise our technologies and capabilities in this new world class facility - increasing our productivity and competitiveness."
He said: "We keep hearing the hype about the so-called Northern Powerhouse so why are aerospace and train manufacturers in the north shedding jobs by the hundreds?" Consultation is ongoing with trade unions and staff.
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